Endocrine Abstracts

Introduction: Critical illness, and sepsis in particular, drives adipose tissue lipolysis up (with triglycerides (TG) being split to free fatty acids (FFA) and glycerol (GLYC)) to meet increased energy demands. Few studies have addressed lipolysis with tissue microdialysis (MD).Aim: To assess indexes of lipolysis in septic patients with and without shock.Subjects and methods: The study included 110 men and 73 women (mean age+<small...

Hyperandrogenism in women, most typically in polycystic ovary syndrome, is associated with insulin resistance and altered morphology and function of adipose tissue but little is known about the direct effects of androgen on adipose. The aims of this study were to investigate (1) distribution and relative abundance of androgen receptor (AR) in mouse adipose tissue (2) effect of temperature on AR expression in brown and white adipose depots (BAT, WAT) and (3) effects of androgen...

Acromegaly is a disease characterized by the presence of a pituitary ademona which secretes excessive amounts of growth hormone. The presence of an adenoma causing acromegaly in the context of multiple endocrine neoplasia syndromes has been described. However, the presence of solitary pituitary adenomas causing acromegaly in siblings is extremely rare.Aim: The aim was to describe acromegaly in 2 siblings.A male patient, aged 56 yea...

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...

Background: PCOS is characterized from chronic anovulation, clinically expressed as menstrual irregularities, hyperandrogenism and polycystic ovaries on ultrasound. A growing body of data indicates that PCOS is a life existing disease starting before puberty and lasting post menopause, as hormonal and metabolic changes exist through the life span of the patient. Since the presence of menstrual irregularities constitutes a prerequisite for the diagnosis of PCOS, we wonder if th...

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

Introduction: Several studies have investigated determinants for androgen levels in men, but few studies have included women. Epidemiological evidence has suggested that cigarette smoking has an anti-oestrogenic effect in women, but the effects of smoking on steroid hormone metabolism are not fully understood. We investigated whether there is a relationship between androgen levels and smoking in perimenopausal women.Material and methods: We examined 75 p...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Case report: Hirsutism although common in acromegaly (24%) is not considered as the prevalent symptom of the disease. Here we describe a seventy-one year old woman with a 2-year history of hyperandronism and subtle acromegalic features (macroglossia, sleep apnea). Clinical examination showed hirsutism (Ferrimann-Gallwey score 20/34), acanthosis nigricans and mild clitoridomegaly. Blood examination revealed elevated IGF-1: 502 ng/ml (69–200 ng/ml) and standard oral glucose...

IntroductionAlemtuzumab is an anti-CD52 antibody, leading to lysis and transient depletion of T and B lymphocytes. Its therapeutic effect is mediated by the alteration in immune repertoire that accompanies subsequent lymphocyte reconstitution. It is mainly used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Common side effects are autoimmune diseases, including thyroid disease (>40%), immune thrombocytopenia (IT...